Sciences Essay代写:压片压缩

2017-02-20 13:05

在压片压缩过程中，崩解颗粒变形，当它们与水介质或水接触时，这些变形颗粒进入正常结构（图2）。偶尔，淀粉的溶胀能力提高时，颗粒被广泛压缩变形。这种增加的变形颗粒的大小产生的片剂的破碎。这可能是淀粉的一种机制，最近才开始研究。12。较好的崩解性能比最广泛使用的合成超崩解剂如AC二溶胶在FDT的配方的研究表明，提取的粘液是一种很好的医药辅料，特别是粉碎agent.18。芒果皮果胶芒果皮构成20–25%的芒果加工废物被发现的优质果胶提取一个很好的源码，适合于制备薄膜和可接受的果冻。果胶是一种复杂的异多糖是一种亲水性胶体。

Sciences Essay代写:压片压缩

During tablet compression, disintegrated particles get deformed and these deformed particles get into their normal structure when they come in contact with aqueous media or water (Fig. 2). Occasionally, the swelling capacity of starch was improved when granules were extensively deformed during compression. This increase in size of the deformed particles produces a breakup of the tablet. This may be a mechanism of starch and has only recently begun to be studied. 12. better disintegrating property than the most widely used synthetic superdisintegrants like Ac-di-sol in the formulations of FDT’s. Studies indicated that the extracted mucilage is a good pharmaceutical adjuvant, specifically a disintegrating agent.18. Mango peel pectin Mango peel which constitutes 20–25% of the mango processing waste was found to be a good source for the extraction of pectin of good quality, suitable for the preparation of fiim and acceptable jelly. Pectin is a complex hetro-polysacharides which is a hydrophilic colloid. Malviya et al (2011) investigated that mango peel pectin stand as a good candidate as superdisintegrant though, not as stronger as synthetic superdisintegrant but due to its good solubility and higher swelling index, it may be used in the formulation of fast dispersible tablets.19-20 Agar and treated agar Agar is the dried gelatinous substance obtained from Gelidium amansii (Gelidanceae) and several other species of red algae like Gracilaria ( Gracilariaceae) and Pterocadia (Gelidaceae). Agar is yellowish gray or white to nearly colorless, odorless with mucilaginous taste and is available in the form of strips, sheet flakes or coarse powder. Agar consists of two polysaccharides as agarose and agaropectin. Agarose is responsible for gel strength and Agaropectin is responsible for the viscosity of agar solutions. High gel strength of agar makes it a potential candidate as a disintegrant. Guar gum Guar gum is mainly consisting of the high molecular weight (approximately 50,000-8,000,000) polysaccharides composed of galactomannans and is obtained from the endosperm of the seed of the guar plant, Cyamopsis tetragonaloba (L) Taub. (syn. Cyamopsis psoraloides). It is used as thickener, stabilizer and emulsifier, and approved in most areas of the world (e.g. EU, USA, Japan, and Australia. It is naturally occurring gum (marketed under the trade name jaguar). It is free flowing, completely soluble, neutral polymer composed of sugar units and is approved for use in food. It is not sensitive to pH, moisture contents or solubility of the tablet matrix. It is not always pure white and sometimes varies in color from off-white to tan tends to discolor with time in alkaline tablets.21 Gellan gum Gellan gum is a water-soluble polysaccharide produced by Pseudomonas elodea, a bacterium. Gellan gum is an anionic, high molecular weight, deacetylated exocellular polysaccharide gum produced as a fermentation product by a pure culture of Pseudomonas elodea2, with a tetrasaccharide repeating unit of one α-L-rhamnose, one β-D-glucuronic acid and two β-D-glucose residues. Antony et al 1997 studied the Gellan gum as a disintegrant and the efficiency of gum was compared with other conventional disintegrants such as dried corn starch, explotab, avicel (pH 10.2), Ac-di-sol. and Kollidon CL. The disintegration of tablet might be due to the instantaneous swelling characteristics of gellan gum when it comes into contact with water and owing to its high hydrophilic nature. The complete disintegration of tablet was has proved itself as superior disintegrant.22